中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (10): 4878-4879.doi: 10.4103/NRR.NRR-D-25-01373

• 观点:退行性病与再生 • 上一篇    下一篇

RNA结合蛋白通过R环动力学调控神经元转录

  

  • 出版日期:2026-10-15 发布日期:2026-06-13

Regulation of neuronal transcription by RNA-binding proteins via R-loop dynamics

Shruti Singh Kakan, Ximena Corso-Díaz*   

  1. Department of Ophthalmology, Byer’s Eye Institute, Stanford School of Medicine, Stanford University, Palo Alto, CA, USA
  • Online:2026-10-15 Published:2026-06-13
  • Contact: Ximena Corso-Díaz, PhD, ximenac@stanford.edu.
  • Supported by:
    This work was supported by the National Eye Institute, grant number R00EY030918 and the Association for Research in Vision and Ophthalmology (ARVO) Genentech Career Development Award to XCD.

摘要: https://orcid.org/0009-0001-0230-7757 (Ximena Corso-Díaz)

Abstract: Neuronal cells require precise and stable control of gene expression throughout their extended lifespan, which presents numerous challenges for gene transcription. While traditional studies of transcriptional regulation have primarily focused on canonical DNA-binding factors, there is an increasing recognition of the role of regulatory RNAs and RNA-binding proteins (RBPs) in modulating this process. A wide repertoire of RNAs is expressed in eukaryotic cells, including many forms of non-coding RNAs that are transcribed from most genomic regions (Djebali et al., 2012). The majority of these non-coding RNAs play crucial roles in genome regulation, functioning both as products and regulators of gene transcription.