中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (21): 1618-1623.

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

Electroacupuncture stimulation of the brachial plexus trunk on the healthy side promotes brain-derived neurotrophic factor mRNA expression in the ischemic cerebral cortex of a rat model of cerebral ischemia/reperfusion injury

  

  • 收稿日期:2012-04-15 修回日期:2012-05-14 出版日期:2012-07-25 发布日期:2012-07-25

Electroacupuncture stimulation of the brachial plexus trunk on the healthy side promotes brain-derived neurotrophic factor mRNA expression in the ischemic cerebral cortex of a rat model of cerebral ischemia/reperfusion injury

Zongjun Guo1, Lumin Wang2   

  1. 1  Department of Special Health Care, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
    2  Department of Emergency Treatment, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
  • Received:2012-04-15 Revised:2012-05-14 Online:2012-07-25 Published:2012-07-25
  • Contact: Zongjun Guo, Department of Special Health Care, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China guozjj@163.com
  • About author:Zongjun Guo☆, M.D., Chief physician, Professor, Department of Special Health Care, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China

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Abstract:

A rat model of cerebral ischemia/reperfusion was established by suture occlusion of the left middle cerebral artery. In situ hybridization results showed that the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after cerebral ischemia/ reperfusion injury. Low frequency continuous wave electroacupuncture (frequency 2-6 Hz, current intensity 2 mA) stimulation of the brachial plexus trunk on the healthy (right) side increased the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic cerebral cortex  14 days after cerebral ischemia/reperfusion injury. At the same time, electroacupuncture stimulation of the healthy brachial plexus truck significantly decreased neurological function scores and alleviated neurological function deficits. These findings suggest that electroacupuncture stimulation of the brachial plexus trunk on the healthy (right) side can greatly increase brain-derived neurotrophic factor mRNA expression and improve neurological function.

Key words: ischemia/reperfusion, brain-derived neurotrophic factor, electroacupuncture, brachial plexus trunk, cerebral cortex, in situ hybridization, neural regeneration