中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (26): 2075-2079.

• 综述:神经损伤修复保护与再生 • 上一篇    

神经元Fcy受体作为免疫球蛋白G新颖的调节者:复杂诱因导致的外围敏感化

  

  • 收稿日期:2012-05-21 修回日期:2012-06-30 出版日期:2012-09-15 发布日期:2012-09-15

Neuronal Fc gamma receptor I as a novel mediator for IgG immune complex-induced peripheral sensitization

Lintao Qu   

  1. Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA
  • Received:2012-05-21 Revised:2012-06-30 Online:2012-09-15 Published:2012-09-15
  • Contact: Lintao Qu, Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven 06510, CT, USA lintao.qu@yale.edu
  • About author:Lintao Qu☆, M.D., Ph.D., Associate research scientist, Department of Anesthesiology, Yale University School of New Haven 06510, CT, USA

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Abstract:

Chronic pain often accompanies immune-related diseases with an elevated level of IgG immune complex (IgG-IC) in the serum and/or the affected tissues though the underlying mechanisms are largely unknown. Fc gamma receptors (FcγRs), known as the receptors for the Fc domain of immunoglobulin G (IgG), are typically expressed on immune cells. A general consensus is that the activation of FcγRs by IgG-IC in such immune cells induces the release of proinflammatory cytokines from the immune cells, which may contribute to the IgG-IC-mediated peripheral sensitization. In addition to the immune cells, recent studies have revealed that FcγRI, but not FcγRII and FcγRIII, is also expressed in a subpopulation of primary sensory neurons. Moreover, IgG-IC directly excites the primary sensory neurons through neuronal FcγRI. These findings indicate that neuronal FcγRI provides a novel direct linkage between immunoglobulin and primary sensory neurons, which may be a novel target for the treatment of pain in the immune-related disorders. In this review, we summarize the expression pattern, functions, and the associated cellular signaling of FcγRs in the primary sensory neurons.

Key words: immunoglobulin G, calcium, immune complex, Fc gamma receptor, primary sensory afferents, pain, transient receptor potential canonical 3, dorsal root ganglion, nonselective cation channel, voltage-gated calcium channel