中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (4): 308-312.

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

Skin electrodes transduced signals to the bladder resulting in ameliorated hypomotility in a rabbit model of diabetes

  

  • 收稿日期:2011-10-08 修回日期:2012-01-05 出版日期:2012-02-05 发布日期:2012-02-05

Skin electrodes transduced signals to the bladder resulting in ameliorated hypomotility in a rabbit model of diabetes

Xinmin Wang1, Qirui Fu1, Qingmei Zhang1, Ping Xu1, Lin Cao1, Meng Xue1, Wei Wang2   

  1. 1  Department of Endocrinology and Metabolism, the Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, Guangdong Province, China
    2  Department of Physics & Astronomy, McMaster University, Medical Physics, Hamilton L8S 4L8, Ontario, Canada
  • Received:2011-10-08 Revised:2012-01-05 Online:2012-02-05 Published:2012-02-05
  • Contact: Wei Wang, Department of Physics & Astronomy, McMaster University, Medical Physics, Hamilton L8S 4L8, Ontario, Canada rowena42110@hotmail.com
  • About author:Xinmin Wang☆, M.D., Professor, Department of Endocrinology and Metabolism, the Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, Guangdong Province, China

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Abstract:

Electric signals from a chest skin electrode can be conducted to the heart and activate contraction. In the present study, normal and diabetic rabbits were stimulated by skin electrode on the abnormal bladder projection area using three levels of exporting voltage (5.84 V, 8.00 V, and 11.00 V). Results demonstrated significantly attenuated electric signals from both groups, in particular the diabetes group. The skin electrode signals were conducted to the bladders, and all vesical signals increased according to strength of stimulating signals from the skin electrode. However, vesical signals from diabetic rabbits were less than those from normal rabbits at the same stimulating strength of exporting voltage. Vesical pressures from the two groups increased along with increased vesical signals, but vesical pressure was less those from diabetic rabbits than in normal rabbits (basic status and different stimulating levels). Linear correlation analysis showed a significantly positive correlation between vesical pressure and signal. These results demonstrated that electric signals from skin electrodes resulted in increased vesical pressure, and vesical pressure increased along with stimulation strength.

Key words: diabetes mellitus, peripheral neurogenic bladder, vesical pressure, vesical stimulation