中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (12): 1922-1923.doi: 10.4103/1673-5374.169624

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

自愈性水凝胶可以修复损伤中枢神经

  

  • 收稿日期:2015-09-30 出版日期:2015-12-30 发布日期:2015-12-30

Self-healing hydrogel for tissue repair in the central nervous system

Fu-Yu Hsieh, Ting-Chen Tseng, Shan-hui Hsu*   

  1. Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, China (Hsieh FY, Tseng TC, Hsu SH)
    Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan, China (Hsu SH)
    Research and Development Center for Medical Devices, National Taiwan University, Taipei, Taiwan, China (Hsu SH)
  • Received:2015-09-30 Online:2015-12-30 Published:2015-12-30
  • Contact: Shan-hui Hsu, Ph.D., shhsu@ntu.edu.tw.

摘要:

中枢神经系统疾病包括阿尔茨海默病、癫痫、脑肿瘤、脑血管疾病(脑卒中,偏头痛和其他头痛症)、多发性硬化症、帕金森病和神经感染等。可注射水凝胶,即自愈水凝胶,是中枢神经系统是再生医学中快速拓展的新学科。大部分神经干细胞疗法可与水凝胶结合修复损伤中枢神经。文章中突出强调了壳聚糖基自修复水凝胶修复损伤中枢神经的功效,并在斑马鱼模型中得到了证实。这种基于壳聚糖的自愈水凝胶是无毒、可生物降解和具有生物相容性。神经干细胞联合基于壳聚糖的自愈水凝胶球状体能够分化成神经元和胶质细胞,并作为具有神经再生潜力的细胞来源。随着该领域的快速发展,我们期待新的智能材料可以随外界刺激发生变化,如剪切、温度、pH值以及特异性配体反应,并能在未来十年内研发出令人兴奋的可以修复中枢神经系统的生物材料。

Abstract:

Neurological disorders are diseases of the central and peripheral nervous systems. These disorders include Alzheimer disease, epilepsy, brain tumor, and cerebrovascular diseases (stroke, migraine and other headache disorders, multiple sclerosis, Parkinson's disease, and neuroinfections. Using injectable hydrogels, and especially injectable, self-healing hydrogels, for local and controlled cell delivery to CNS is a fast and new expanding discipline of regenerative medicine. A multitude of molecular and NSC therapeutics can be combined with hydrogels to repair injured CNS. In this status review, we have highlighted the chitosan-based self-healing hydrogel with CNS repair efficacy which was supported by the zebrafish model. The chitosan-based self-healing hydrogel is nontoxic, biodegradable, and biocompatible. NSC spheroids within chitosan-based self-healing hydrogel are able to differentiate into neurons and glial cells as a potential cellular source for neural regeneration. The zebrafish neural injury model may be used to screen potential biomaterials for applications in CNS related diseases. With the recent advances, we expect new smart materials that can respond to changes in external stimuli such as shear, temperature, pH, and specific ligands will be developed in the near future to provide exciting possibilities to repair CNS related diseases in the next ten years.