中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (2): 208-210.doi: 10.4103/1673-5374.152371

• 观点:退行性病与再生 • 上一篇    下一篇

胶质HO-1抑制剂允许神经退行性疾病的神经修复吗?

  

  • 收稿日期:2015-01-09 出版日期:2015-02-17 发布日期:2015-02-17

Is glial heme oxygenase-1 suppression in neurodegenerative disorders permissive for neural repair?

Hyman M. Schipper   

  1. Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Department of Neurology &
    Neurosurgery and Department. of Medicine, McGill University, Montreal, Quebec, Canada
  • Received:2015-01-09 Online:2015-02-17 Published:2015-02-17
  • Contact: Hyman M. Schipper, M.D., Ph.D., F.R.C.P.C.,hyman.schipper@mcgill.ca.
  • Supported by:

    Dr. Schipper’s laboratory is supported by grants from the Canadian Institutes of Health Research, the Mary Katz Claman Foundation and the Oberfeld Family Fund for Alzheimer Research.

摘要:

在当代神经科学领域,一个优先问题是哪种欠缺的修复机制和神经可塑性可以逆转中枢神经系统受损?在阿尔茨海默病的APP转基因小鼠模型、阿尔茨海默病和额颞叶痴呆症的突变tau蛋白驱动模型、帕金森病MPTP小鼠模型、亨廷顿病啮齿动物模型以及几个模拟脊髓小脑变性模型中已发现神经可塑性和神经恢复的证据。