中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (12): 2105-2107.doi: 10.4103/1673-5374.241459

• 观点:退行性病与再生 • 上一篇    下一篇

基于细胞的阿尔茨海默病治疗:人类胎儿胆碱能神经元能“解开绞线”

  

  • 收稿日期:2018-08-13 出版日期:2018-12-15 发布日期:2018-12-15

Cell-based therapy in Alzheimer’s disease: can human fetal cholinergic neurons “untangle the skein”?

Giulia Guarnieri, Erica Sarchielli, Gabriella B. Vannelli, Annamaria Morelli   

  1. Anatomy and Histology Unit, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy
  • Received:2018-08-13 Online:2018-12-15 Published:2018-12-15
  • Contact: Annamaria Morelli, PhD, a.morelli@unifi.it.

摘要:

orcid: 0000-0001-8027-9870 (Annamaria Morelli)

Abstract:

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common form of old-age dementia. The disease is characterized by a progressive decline in cognitive functions, gradual loss of memory and ability to perform everyday activities, and leads to inevitable death within 3 to 9 years after diagnosis. The pathological hallmarks of the disease are the accumulation of intracellular neurofibrillary tangles, composed of the microtubule associated protein tau, and extracellular deposits of amyloid-β (Aβ) plaques, which are overall responsible for an extensive loss of neurons and synaptic connectivity.