中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (1): 36-42.doi: 10.4103/1673-5374.286949

• 综述:退行性病与再生 • 上一篇    下一篇

多发性硬化症的认知障碍:来自脑脊液生物标志物的教训

  

  • 出版日期:2021-01-15 发布日期:2020-11-23

Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers

Lorenzo Gaetani, Nicola Salvadori, Elena Chipi, Lucia Gentili, Angela Borrelli, Lucilla Parnetti, Massimiliano Di Filippo*#br#   

  1. Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy
  • Online:2021-01-15 Published:2020-11-23
  • Contact: Massimiliano Di Filippo, MD, PhD, massimiliano.difilippo@unipg.it.

摘要: https://orcid.org/0000-0002-2645-7477 (Massimiliano Di Filippo) 

Abstract: Cognitive impairment is a common clinical manifestation of multiple sclerosis, but its pathophysiology is not completely understood. White and grey matter injury together with synaptic dysfunction do play a role. The measurement of biomarkers in the cerebrospinal fluid and the study of their association with cognitive impairment may provide interesting in vivo evidence of the biological mechanisms underlying multiple sclerosis-related cognitive impairment. So far, only a few studies on this topic have been published, giving interesting results that deserve further investigation. Cerebrospinal fluid biomarkers of different pathophysiological mechanisms seem to reflect different neuropsychological patterns of cognitive deficits in multiple sclerosis. The aim of this review is to discuss the studies that have correlated cerebrospinal fluid markers of immune, glial and neuronal pathology with cognitive impairment in multiple sclerosis. Although preliminary, these findings suggest that cerebrospinal fluid biomarkers show some correlation with cognitive performance in multiple sclerosis, thus providing interesting insights into the mechanisms underlying the involvement of specific cognitive domains. 

Key words: biomarkers, cerebrospinal fluid, cognitive impairment, information processing speed, memory, multiple sclerosis