中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (1): 43-48.doi: 10.4103/1673-5374.286950

• 综述:退行性病与再生 • 上一篇    下一篇

NG2胶质细胞的后代:我们从转基因小鼠模型中学到什么?

  

  • 出版日期:2021-01-15 发布日期:2020-11-23

Progenies of NG2 glia: what do we learn from transgenic mouse models ?

Qilin Guo, Anja Scheller, Wenhui Huang*   

  1. Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, Homburg, Germany
  • Online:2021-01-15 Published:2020-11-23
  • Contact: Wenhui Huang, PhD, wenhui.huang@uks.eu.
  • Supported by:
    This work was supported by grants from the Deutsche Forschungsgemeinschaft DFG Sino-German joint project (Kl 503/14-1) to WH, DFG FOR 2289 to AS; from the Saarland University Medical Faculty HOMFOR2015 and HOMFORexzellenz2016 to AS and WH, respectively. WH was also supported by DFG SFB 894 and the European Commission EC-H2020 FET ProAct Neurofibres.

摘要:

https://orcid.org/0000-0002-7531-0818 (Qilin Guo); 

https://orcid.org/0000-0001-8955-2634 (Anja Scheller); 

https://orcid.org/0000-0001-9865-0375 (Wenhui Huang)

Abstract: In the mammalian central nervous system, nerve-glia antigen 2 (NG2) glia are considered the fourth glial population in addition to astrocytes, oligodendrocytes and microglia. The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy. There is a clear agreement that NG2 glia mainly serve as progenitors for oligodendrocytes and a subpopulation of astrocytes mainly in the ventral forebrain, whereas the existence of a neurogenic potential of NG2 glia is lack of adequate evidence. This mini review summarizes the findings from recent studies regarding the fate of NG2 glia during development. We will highlight the age-and-region-dependent heterogeneity of the NG2 glia differentiation potential. We will also discuss putative reasons for inconsistent findings in various transgenic mouse lines of previous studies. 

Key words: astrogliogenesis, cell fate, Cre/loxP system, development, differentiation, embryonic brain, neurogenesis, NG2 glia, oligodendrocyte lineage, oligodendrocyte precursor cells