中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (9): 1711-1714.doi: 10.4103/1673-5374.306060

• 综述:退行性病与再生 • 上一篇    下一篇

慢性外周炎症:神经退行性疾病的可能因素

  

  • 出版日期:2021-09-15 发布日期:2021-02-05

Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases

Patrick Süβ1, Addison J. Lana2, Johannes C. M. Schlachetzki2, *   

  1. 1Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany; 2Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA
  • Online:2021-09-15 Published:2021-02-05
  • Contact: Johannes C. M. Schlachetzki, MD, jschlachetzki@health.ucsd.edu.

摘要: https://orcid.org/0000-0002-7801-9743 (Johannes C. M. Schlachetzki) 

Abstract: The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma. 

Key words: aging, Alzheimer’s disease, inflammation, innate immune system, microglia, neurodegeneration, Parkinson’s disease