中国神经再生研究(英文版) ›› 2021, Vol. 21 ›› Issue (5): 1985-1986.doi: 10.4103/NRR.NRR-D-24-01657

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

铁平衡失调与肥胖和神经系统疾病有关

  

  • 出版日期:2026-05-15 发布日期:2025-08-22

Iron dyshomeostasis links obesity and neurological diseases

Bandy Chen*   

  1. Department of Medicine, UC San Diego School of Medicine, La Jolla, CA, USA
  • Online:2026-05-15 Published:2025-08-22
  • Contact: Bandy Chen, bac008@health.ucsd.edu.

摘要: https://orcid.org/0009-0009-9099-1218 (Bandy Chen)

Abstract: With the industrialization of agriculture and the advancement of medical care, human life expectancy has increased considerably and continues to rise steadily. This results in novel and unprecedented challenges, namely obesity and neurodegeneration. Understanding the intimate link between these two pathologies will enhance our understanding of brain-body crosstalk to develop effective treatments to halt the rising rates of obesity and neurological disorders. Obesity increases the risk of cognitive decline and neurological disorders; however, it remains unclear the exact mechanisms of obesity-induced neurodegeneration. This perspective proposes iron as a nexus between obesity and neurological disorders through the reshaping of the neuro-glialvascular landscape.