中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (11): 2420-2422.doi: 10.4103/1673-5374.335789

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

大脑类器官中设计大脑折叠

  

  • 出版日期:2022-11-15 发布日期:2022-04-22

Engineering cerebral folding in brain organoids

Glen Scott, Yu Huang*   

  1. Biological Engineering, College of Engineering, Utah State University, Logan, UT, USA
  • Online:2022-11-15 Published:2022-04-22
  • Contact: Yu Huang, PhD, yu.huang@usu.edu.
  • Supported by:
    GS was partially supported by USU’s Engineering Undergraduate Research Program; GS and YH were partially supported by NIH NIGMS fund, No. R15GM132877; YH was also partially supported by NIH NIGMS fund, No. R35GM143194.

摘要: https://orcid.org/0000-0002-1859-3380 (Yu Huang)

Abstract: Neurological diseases remain the largest cause of death and disability. The discovery of effective therapies is chiefly hindered by the lack of realistic neurological models. Unlike other tissues, it is infeasible or unethical to access primary human neural samples in bulk. But animal models often fail to replicate the complex human-specific neuronal factors present in vivo. Conventional in vitro cultures lack native three-dimensional (3D) morphologies, polarity, and receptor expression, as well as tissue-level interactions (Jensen et al., 2018).