中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (12): 2651-2652.doi: 10.4103/1673-5374.373709

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

关注LPA信号:促进免疫介导性神经病再生的一个有前途的治疗靶点

  

  • 出版日期:2023-12-15 发布日期:2023-06-14

Focus on LPA signaling: a promising therapeutic target to foster regeneration in immune-mediated neuropathies

Fabian Szepanowski*, Mark Stettner   

  1. Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS), University Medicine Essen, University Duisburg Essen, Essen, Germany
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Fabian Szepanowski, PhD, fabian.szepanowski@uk-essen.de.

摘要: https://orcid.org/0000-0003-2744-5416 (Fabian Szepanowski)

Abstract: Lysophospholipids are metabolites of glycerophospholipids and sphingolipids that are commonly found as lipid constituents of cell membranes. In addition to their function as structural membrane components, certain members of the lysophospholipid family have considerable cell signaling properties. Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) represent the two major bioactive members of the lysophospholipid family that address specific G-protein coupled receptors, simply referred to as S1P (subtypes S1P1–5) and LPA (subtypes LPA1–6) receptors (Kano et al., 2022). Lysophospholipid signaling has a wide range of physiological functions and potential pathophysiological effects in the adult organism, but also plays important roles during embryonic development, especially in the development of the nervous, vascular and immune system (Kano et al., 2022).