中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (3): 495-496.doi: 10.4103/1673-5374.380896

• 观点:退行性病与再生 • 上一篇    下一篇

通过BDNF/TrkB信号通路诱导神经元再生和分化:抗神经退行性疾病的关键靶点?

  

  • 出版日期:2024-03-15 发布日期:2023-09-01

Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway: a key target against neurodegenerative diseases?

Mirjana Antonijevic,  Patrick Dallemagne,  Christophe Rochais*   

  1. Normandie University, UNICAEN, CERMN, Caen, France
  • Online:2024-03-15 Published:2023-09-01
  • Contact: Christophe Rochais, PhD, christophe.rochais@unicaen.fr.
  • Supported by:
    This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 765704 (to CR).

摘要: https://orcid.org/0000-0001-7996-2082 (Christophe Rochais)

Abstract: Brain-derived neurotrophic factor (BDNF) is one of the neurotrophins, a specific polypeptide growth factor, which plays a crucial role in the proliferation, differentiation, survival, and death of neurons and non-neuronal cells. It is not only essential to maintain the balance between death on one side and survival of neurons on the other, but also it mediates additional higher-order activities such as learning, memory, and behavior. It is initially synthesized as a precursor protein, proBDNF, that can be secreted as it is or it can be cleaved intracellularly by furin and proconvertases, or extracellularly by extracellular proteases such as matrix metalloprotease-9 and matrix metalloprotease-2, or plasmin to give mature BDNF.