中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (10): 2887-2894.doi: 10.4103/NRR.NRR-D-24-00684

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

核因子 Y复合物在大脑发育过程中的作用方式及基因组技术对其表达的调节

  

  • 出版日期:2025-10-15 发布日期:2025-02-07

Functions of nuclear factor Y in nervous system development, function and health

Pedro Moreira* , Roger Pocock*   

  1. Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC, Australia
  • Online:2025-10-15 Published:2025-02-07
  • Contact: Pedro Moreira, PhD, pedro.moreira@monash.edu; Roger Pocock, PhD, roger.pocock@monash.edu.
  • Supported by:
    This work was supported by National Health and Medical Research Council GNT1105374, GNT1137645, GNT2000766 and veski Innovation Fellowship (VIF23) to RP.

摘要: https://orcid.org/0000-0002-4852-0318 (Pedro Moreira); https://orcid.org/0000-0002-5515-3608 (Roger Pocock) 

Abstract: Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes, one of the most common motifs found in gene promoters and enhancers. Over the last 30 years, research has revealed that the nuclear factor Y complex controls many aspects of brain development, including differentiation, axon guidance, homeostasis, disease, and most recently regeneration. However, a complete understanding of transcriptional regulatory networks, including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains elusive. In this review, we explore the nuclear factor Y complex’s role and mode of action during brain development, as well as how genomic technologies may expand understanding of this key regulator of gene expression.

Key words: axon guidance,  , CCAAT boxes,  , neuronal degeneration,  , neuronal differentiation,  , neuronal regeneration,  , nuclear factor Y complex,  , transcription factor,  , transcriptional regulation