中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (12): 3535-3536.doi: 10.4103/NRR.NRR-D-24-00853

• 观点:退行性病与再生 • 上一篇    下一篇

大脑皮层对帕金森病震颤的影响:究竟是谁主导产生了震颤?

  

  • 出版日期:2025-12-15 发布日期:2025-03-15

Cerebral cortex contributions to Parkinson’s disease tremor: what exactly generates the tremor?

Manuel Bange* , Hao Ding, Muthuraman Muthuraman   

  1. Informatics for Medical Technology, Institute of Computer Science, University Augsburg, Augsburg, Germany (Bange M, Muthuraman M) Department of Neurology, Neural Engineering with Signal Analytics and Artificial Intelligence (NESA-AI), University Clinic Würzburg, Würzburg, Germany (Ding H, Muthuraman M)
  • Online:2025-12-15 Published:2025-03-15
  • Contact: Dr. Manuel Bange, manuel.bange@uni-a.de.
  • Supported by:
    This work was supported by the German Research Foundation (SFB-TR 295) (to MM).

摘要: https://orcid.org/0000-0002-5247-8810 (Manuel Bange)

Abstract: Pathological tremor is one of the cardinal symptoms in Parkinson’s disease (PD). Tremor is comprised of involuntary, rhythmic, and oscillating movements that can vary according to the circumstances under which they occur, the body parts that are involved, and the frequency at which they present. For example, tremors can be mild to severe, are stress sensitive, and can affect arms, legs, or the head (Dirkx and Bologna, 2022). Furthermore, it can appear at rest (rest tremor), while holding a posture (postural tremor), or even during active movement (kinetic tremor). Among these variants, rest tremor is the most common manifestation, usually expressing itself as an asymmetric, pill-rolling movement of the hands at frequencies from 4 to 6 Hz which is inhibited during voluntary movement. Paradoxically, people with rest tremors may additionally experience a tremor that re-appears after a brief delay (on average 10 seconds) when maintaining a stable postural position, a phenomenon known as reemergent tremor (Jankovic et al., 1999). Given that the phenomenological and electrophysiological characteristics of rest and re-emergent tremor are similar and patients with re-emergent tremor do not differ clinically from patients with isolated rest tremor, re-emergent tremor was initially suggested to be a clinical variant of rest tremor and assumed to share the same central tremor circuit (Jankovic et al., 1999).