中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (4): 1558-1559.doi: 10.4103/NRR.NRR-D-24-01556

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤后神经元肿胀与功能恢复有关

  

  • 出版日期:2026-04-15 发布日期:2025-07-27

Neuronal swelling implicated in functional recovery after spinal cord injury

Qiang Li*   

  1. Department of Neurobiology, University of Texas Medical Branch, Galveston, TX, USA Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Online:2026-04-15 Published:2025-07-27
  • Contact: Qiang Li, PhD, qili3@mgh.harvard.edu.

摘要: https://orcid.org/0000-0002-0984-1514 (Qiang Li)

Abstract: Spinal cord injury (SCI) often results in permanent dysfunction of locomotion, sensation, and autonomic regulation, imposing a substantial burden on both individuals and society (Anjum et al., 2020). SCI has a complex pathophysiology: an initial primary injury (mechanical trauma, axonal disruption, and hemorrhage) is followed by a progressive secondary injury cascade that involves ischemia, neuronal loss, and inflammation. Given the challenges in achieving regeneration of the injured spinal cord, neuroprotection has been at the forefront of clinical research. Yet, current neuroprotective therapeutic efficiency is limited (Anjum et al., 2020). To develop effective neuroprotective interventions for SCI patients, a deeper understanding of SCI pathophysiology is undoubtedly required.