中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (6): 2369-2369.doi: 10.4103/NRR.NRR-D-25-01676

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

评论“通过机械调节Il11ra1+/Itga11+成纤维细胞的排列模式来针对纤维化瘢痕,可促进脊髓损伤后的轴突生长”

  

  • 出版日期:2026-06-15 发布日期:2026-04-16

Commentary on: “Targeting fibrotic scarring by mechanoregulation of Il11ra1+/Itga11+ fibroblast patterning promotes axon growth after spinal cord injury”

Kwok-Fai So*   

  1. Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China;  State Key Laboratory of Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
  • Online:2026-06-15 Published:2026-04-16
  • Contact: Kwok-Fai So, PhD, hrmaskf@hku.hk.

摘要: https://orcid.org/0000-0003-4039-4246 (Kwok-Fai So)
 

Abstract: The fibrotic scar due to excessive deposition of extracellular matrix (ECM) after spinal cord injury (SCI) remains one of formidable challenges to axonal regeneration. Previous therapeutic strategies mainly focus on eliminating fibrotic scars by blocking (Göritz et al., 2011) or inhibiting (Dias et al., 2018) the generation of scar-forming stromal cells, as well as inducing their migratory defect (Hellal et al., 2011; Ruschel et al., 2015). Although these approaches help reduce fibrotic scarring, it is insufficient to fully reverse the pathological consequences of fibrosis. Increasing evidence shows that fibrotic scars actually play important positive roles by sealing the lesion and preserving tissue integrity. Moreover, interactions between regenerating axons and ECM are indispensable for axonal elongation and growth (Anderson et al., 2018). This dual nature of healthy physiological ECM and pathological scars means that eliminating the fibrotic scar is not ideal for SCI repair.