中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (7): 2555-2562.doi: 10.4103/NRR.NRR-D-25-00342

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

高尔基体在星形胶质细胞功能中的有趣作用:对疾病的影响

  

  • 出版日期:2026-07-15 发布日期:2025-10-17

Intriguing role of the Golgi apparatus in astrocyte function: Implications for disorders

Martina Polenghi1, #, Elena Restelli1, #, Elena Taverna1 , Laura Tapella2, *   

  1. 1 Human Technopole, Neurogenesis Research Center, Milan, Italy;  2 Department of Pharmaceutical Sciences, Università del Piemonte Orientale “Amedeo Avogadro”, Novara, Italy
  • Online:2026-07-15 Published:2025-10-17
  • Contact: Laura Tapella, PhD, laura.tapella@uniupo.it.

摘要: https://orcid.org/0000-0002-8159-1628 (Laura Tapella)

Abstract: Cell function has a tight relationship with cell architecture. Distribution of proteins to the correct compartment is one of the functions of the traffic pathway through the Golgi apparatus. The others are to ensure proper protein folding, the addition of post-translational modifications, and delivering to intracellular and extracellular destinations. Astrocytes are fundamental homeostatic cells, controlling multiple aspects of the central nervous system physiology, such as ion balance, nutrients, blood flow, neurotransmitters, and responses to insults. Astrocytes are polarized cells, and, such as neurons, extensively use the secretory pathway for secreting factors and exposing functional receptors, channels, and transporters on the plasma membrane. In this review, we will underline the importance of studying the Golgi apparatus and the secretory pathway in astrocytes, based on the possible tight connection between the Golgi apparatus and astrocytes’ homeostatic function. Given the topic of this review, we will provide examples mostly about the Golgi apparatus structure, function, localization, and its involvement in astrocytes’ homeostatic response, with an insight into congenital glycosylation disorders, as an example of a potential future field in the study of astrocyte homeostatic failure and Golgi apparatus alteration.

Key words: astrocytes, congenital glycosylation disorders, glia, Golgi apparatus, homeostatic function, local protein translation, neurodegeneration, neuroinflammation, neuronal development, secretory pathway