中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (7): 2684-2698.doi: 10.4103/NRR.NRR-D-25-00190

• 综述:退行性病与再生 • 上一篇    下一篇

脑特异性microRNA与阿尔茨海默病的互作

  

  • 出版日期:2026-07-15 发布日期:2025-10-17

Interplay between brain-specific microRNAs and Alzheimer’s disease

Nathan Tinu1 , Bhupender Sharma1 , Daniela Rodarte1 , Rajkumar Lakshmanaswamy2, 3, Subodh Kumar1, 2, *   

  1. 1 Center of Emphasis in Neuroscience, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, TX, USA;  2 L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, TX, USA;  3 Center of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, TX, USA
  • Online:2026-07-15 Published:2025-10-17
  • Contact: Subodh Kumar, PhD, subodh.kumar@ttuhsc.edu.
  • Supported by:
    This work was funded by the National Institute on Aging (NIA), National Institutes of Health (NIH), Nos. K99AG065645, R00AG065645, R00AG065645- 04S1; SARP mini grants TTUHSC EP, Edward N. & Margaret G. Marsh Foundation and TTUHSC EP MTM Startup Funds (all to SK).

摘要: https://orcid.org/0000-0003-4705-122X (Subodh Kumar) 

Abstract: Alzheimer’s disease is a progressive neurodegenerative disease characterized by memory decline and the accumulation of abnormal protein aggregates in the brain. While the precise cause of Alzheimer’s disease remains under investigation, recent research suggests that dysregulation of brainspecific microRNAs (miRs) plays a significant role in Alzheimer’s disease pathogenesis. Brain-specific miRs are predominantly expressed within the central nervous system and are crucial for neuronal development, and function, potentially in brain disorders. This review identifies some key brainspecific miRs in Alzheimer’s disease, including miR-9, miR-26b, miR-34a, miR-107, miR-124, miR125b, miR-128, miR-132, miR-146a, miR-155, miR-219, miR-501-3p, and miR-502-3p. The review also shed light on the brain-specific location of these miRs, their dysregulation in Alzheimer’s disease, and how they are involved in disease progression. Apparently, these brain-specific miRs modulate specific genes and are therefore crucial for various cellular processes, including autophagy, cell cycle, tau phosphorylation, amyloid-beta production, and neuroinflammation. Moreover, these miRs are potent disease-modifying factors and their expression levels could serve as potential biomarkers for diagnosing or monitoring Alzheimer’s disease progression.

Key words: Alzheimer’s disease, biomarker, brain function, microRNAs, therapeutics