中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (7): 2834-2835.doi: 10.4103/NRR.NRR-D-25-00161

• 观点:退行性病与再生 • 上一篇    

衰老过程中蛋白质稳态衰退和内质网应激:对细胞衰老和衰老相关分泌表型调控的影响

  

  • 出版日期:2026-07-15 发布日期:2025-10-20

Proteostasis decline and endoplasmic reticulum stress in aging: Implications for cellular senescence and senescence-associated secretory phenotype regulation

Philippe Pihán, Lisa M. Ellerby, Claudio Hetz*   

  1. Buck Institute for Research on Aging, Novato, CA, USA
  • Online:2026-07-15 Published:2025-10-20
  • Contact: Claudio Hetz, PhD, chetz@buckinstitute.org.
  • Supported by:
    This work was supported by NIH NIA 1RO1AG061879 and 5PO1AG066591 (to LME) and FONDAP Program 15150012, ECOS-ANID (ECOS230034), and the US Army Medical Research Acquisition Activity (USAMRAA) AL2201415 (to CH).

摘要: https://orcid.org/0000-0003-1120-7966 (Claudio Hetz)

Abstract: Aging is a universal biological process characterized by the progressive decline in cellular and tissue function, representing the main risk factor for the development of most chronic human diseases. At the cellular level, one hallmark of aging is the accumulation of senescent cells—non-dividing yet metabolically active cells that adopt a unique phenotype, including the senescence-associated secretory phenotype (SASP) (Wang et al., 2024). The SASP encompasses a complex secretory program of bioactive molecules, including proinflammatory cytokines such as interleukin-6, interleukin-1 beta, and tumor necrosis factoralpha; chemokines such as CXC motif chemokine ligand 8/interleukin-8 and C-C motif chemokine ligand 2; growth factors such as vascular endothelial growth factor and hepatocyte growth factor; and matrix-remodeling enzymes such as matrix metalloproteinases. These factors influence the surrounding microenvironment by promoting inflammation, tissue remodeling, and paracrineinduced senescence. While the SASP may play a beneficial role in acute stress responses such as wound healing and tumor suppression, its chronic persistence contributes to systemic inflammation, stem cell exhaustion, and age-associated pathologies (Wang et al., 2024).