中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (8): 3517-3518.doi: 10.4103/NRR.NRR-D-25-00722

• 观点:退行性病与再生 • 上一篇    下一篇

胰岛素受体在小胶质细胞中的作用

  

  • 出版日期:2026-08-18 发布日期:2026-04-25

Establishing a role of the insulin receptor in microglia

William A. Banks, Elizabeth M. Rhea*   

  1. Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA (Banks WA, Rhea EM)
    Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USA (Banks WA, Rhea EM)
  • Online:2026-08-18 Published:2026-04-25
  • Contact: Elizabeth M. Rhea, PhD, meredime@uw.edu.

摘要: https://orcid.org/0000-0001-8118-120X (Elizabeth M. Rhea)
 

Abstract: Brain insulin resistance (BIR) is a prevalent detrimental feature of Alzheimer’s disease (AD) and all-cause dementia. Therapies designed to activate insulin signaling and enhance insulin receptor sensitivity have proven beneficial for cognitive enhancement in pre-clinical models, non-human primates, and humans. BIR encompasses dysregulated brain insulin signaling, which is either due to insulin receptor resistance, reduced insulin receptor levels, or reduced levels of insulin in the brain, affecting processes involved in AD development and progression. While prior work has shown BIR is a nexus between metabolic dysfunction and neurodegenerative disease, a recent work by Chen et al. (2025) re-emphasizes a role of BIR in AD, highlighting microglia as a key mediator. This recent work is a great step forward in answering many of these questions and shows how central insulin receptor resistance of microglia can result in altered cellular metabolism, neuroinflammation, altered mood and social behavior, and accelerated AD pathogenesis