中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (9): 4227-4228.doi: 10.4103/NRR.NRR-D-25-01274

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

灵长类脊髓神经胶质异质性:年龄和性别差异对神经退行性和神经创伤性疾病的影响

  

  • 出版日期:2026-09-15 发布日期:2026-05-11

Glial heterogeneity in the primate spinal cord: Implications of age and sex differences for neurodegenerative and neurotraumatic diseases

Chloé M. Gazard, Gaëtan Poulen, Florence E. Perrin*   

  1. MMDN, Univ. Montpellier, EPHE, INSERM, Montpellier, France (Gazard CM, Poulen G, Perrin FE)
    Department of Neurosurgery, CHU, Montpellier, France (Poulen G)
    Universitaire de France (IUF), Paris, France (Perrin FE)
  • Online:2026-09-15 Published:2026-05-11
  • Contact: Florence E. Perrin, PhD, florence.perrin@umontpellier.fr.

摘要: https://orcid.org/0000-0002-7630-0515 (Florence E. Perrin)

Abstract: The central nervous system (CNS) relies on the intricate interplay between neurons and glial cells to maintain homeostasis and coordinate responses to disease or injury. It is now well established that within this network, astrocytes, microglia, and oligodendrocytes are critical regulator of neural function, actively shaping metabolism, inflammation, and therefore degenerative and repair processes. Glial dysfunction and alteration of dynamic cross-communication among the glial cell population have emerged as a common denominator in both neurodegenerative and neurotraumatic conditions. It is therefore clear that glial cells are not passive bystanders but active contributors to CNS health and disease.