中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (30): 2377-2383.

• 原著:退行性病与再生 • 上一篇    下一篇

尿激酶型纤溶酶原激活剂基因rs2227564位点多态性

  

  • 收稿日期:2012-03-18 修回日期:2012-06-13 出版日期:2012-10-25 发布日期:2012-10-25

Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer’s disease in the Han Chinese population

Xuelian Ji1, Longfei Jia2, Jianping Jia2, Li Qi3   

  1. 1 Department of Neurology, Inner Mongolia People’s Hospital, Huhhot 010017, Inner Mongolia Autonomous Region, China
    2 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
    3 Inner Mongolia Corps Hospital, Chinese People’s Armed Police Forces, Huhhot 010040, Inner Mongolia Autonomous Region, China
  • Received:2012-03-18 Revised:2012-06-13 Online:2012-10-25 Published:2012-10-25
  • Contact: Jianping Jia, M.D., Chief physician, Professor, Doctor-al supervisor, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China jiaxuanwu@126.com
  • About author:Xuelian Ji☆, M.D., Chief physician, Professor, De-partment of Neurology, Inner Mongolia People’s Hospital, Huhhot 010017, Inner Mon-golia Autonomous Region, China

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Abstract:

A missense C/T polymorphism in exon 6 (the NCBI rsID is rs2227564) of the urokinase-type plas-minogen activator gene has been identified as a possible hot spot for Alzheimer’s disease risk. The present study analyzed urokinase-type plasminogen gene polymorphisms of rs2227564 with spo-radic Alzheimer’s disease by PCR-restriction fragment length polymorphism. Results showed that CC, CT and TT genotype distribution frequencies had significant differences between sporadic Alzheimer’s disease patients and healthy controls. In-depth analysis of the association between urokinase-type plasminogen gene rs2227564 polymorphisms and sporadic Alzheimer’s disease in-dicated that people with the C-positive genotype CC + CT were at a higher risk for developing sporadic Alzheimer’s disease. These results support the contribution of the polymorphisms of rs2227564 in the urokinase-type plasminogen gene to the pathogenesis of sporadic Alzheimer’s disease in the Han Chinese population.

Key words: Alzheimer’s disease, urokinase plasminogen activator, polymorphism, genetic testing, Han Chinese population, neural regeneration