中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (30): 2370-2376.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

艾灸预处理足三里穴对神经通路切断后胃黏膜损伤大鼠热休克蛋白70表达的影响

  

  • 收稿日期:2012-03-15 修回日期:2012-06-24 出版日期:2012-10-25 发布日期:2012-10-25

Effects of pre-moxibustion at Zusanli (ST36) on heat shock protein 70 expression in rats with gastric mucosal lesions after neurotomy

Liang Peng, Mi Liu, Xiaorong Chang, Zhou Yang, Shouxiang Yi, Jie Yan, Yan Peng   

  1. College of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
  • Received:2012-03-15 Revised:2012-06-24 Online:2012-10-25 Published:2012-10-25
  • Contact: Xiao-rong Chang, Professor, Doctoral supervisor, College of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China xrchang1956@163.com
  • About author:Liang Peng☆, Ph.D., Lectur-er, College of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China

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Abstract:

Studies have shown that pre-moxibustion protects the gastric mucosa by up-regulating the expression of heat shock protein 70. However, the signaling pathway underlying this effect remains unclear. Rats were intragastrically administered absolute alcohol, causing obvious lesion of the gastric mucosa. Following pre-moxibustion at Zusanli (ST36) for 8 days, the ulcer index decreased to different degrees. The results of an enzyme linked immunosorbent assay and western blotting showed significant upregulation of heat shock protein 70 expression in the gastric mucosa and serum. None out of transection of the spinal cord, damage to the nucleus of the solitary tract, neurotomy of the vagal nerve and neurotomy of the common peroneal nerve affected the decrease in ulcer index or the increase in heat shock protein 70 expression in serum after pre-moxibustion at Zusanli, and heat shock protein 70 expression was obviously decreased in the gastric mucosa. These findings suggest that pre-moxibustion at Zusanli can protect the gastric mucosa against lesioning, and that the mechanism underlying this effect involves its induction of heat shock protein 70 expression. Neural pathways participate in the regulatory effects of moxibustion on heat shock protein 70 expression in the gastric mucosa.

Key words: pre-moxibustion, transection of neural pathway, Zusanli (ST36), gastric mucosal lesion, heat shock proteins-70, ulcer index, traditional Chinese medicine, neural regeneration