中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (29): 2267-2272.

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

周围神经损伤修复中出现的问题

  

  • 收稿日期:2012-05-11 修回日期:2012-07-10 出版日期:2012-10-15 发布日期:2012-10-15

Emerging issues in peripheral nerve repair

Stefano Geuna1, Pierluigi Tos2, Bruno Battiston2   

  1. 1 Neuroscience Institute of the “Cavalieri Ottolenghi” Foundation (NICO) & Department of Clinical and Biological Sciences, University of Turin, Torino 10043, Italy
    2 Department of Traumatology, Microsurgery Unit, C.T.O. Hospital, Torino 10126, Italy
  • Received:2012-05-11 Revised:2012-07-10 Online:2012-10-15 Published:2012-10-15
  • Contact: Setfano Geunea, Neuroscience Institute of the “Cavalieri Ottolenghi” Foundation (NICO) & Department of Clinical and Biological Sciences, University of Turin, Torino 10043, Italy stefano.geuna@unito.it
  • About author:Stefano Geuna☆, M D., Associate professor, Neuroscience Institute of the “Cavalieri Ottolenghi” Foundation (NICO) & Department of Clinical and Biological Sciences, University of Turin, Torino 10043, Italy

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Abstract:

It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that, to further improve clinical outcome, the involvement of different scientific disciplines is required. This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery, transplantation and biomaterials. In this paper, some of the most promising innovations for the tissue engineering of nerves, emerging from basic science investigation, are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation.

Key words: nerve reconstruction, tissue engineering, cell and tissue transplantation, gene therapy, biomaterials, peripheral nervous system, microsurgery, artificial hollow tubes, muscle-vein-combined tubes, non-nervous guides, neural regeneration