1.This is the first demonstration of the bioactive molecules associated with Parkinson’s disease in rat striatum, substantia nigra and blood using modern molecular biology technology, and the first exploration of Zhichan powder’s role in the treatment of Parkinson’s disease.
2.Zhichan powder, a Chinese herbal compound, has an antioxidant effect, can regulate the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson’s disease rats, and facilitate the secretion of striatal dopamine and its metabolite homovanillic acid, resulting in a neuroprotective effect on substantia nigra neurons in Parkinson’s disease rats.
1.实验为首次采用现代分子生物学技术对帕金森模型大鼠脑内黑质、纹状体及血液中与帕金森病有关的生物活性分子进行分析,探讨止颤粉治疗帕金森病的作用机理。
2.结果显示,中药止颤粉具有抗氧化作用,可调节帕金森病模型大鼠脑黑质单胺氧化酶B和酪氨酸羟化酶的表达,促进纹状体多巴胺及代谢产物高香草酸分泌,从而产生对帕金森病大鼠黑质神经元的保护效应。