中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (10): 1565-1567.doi: 10.4103/1673-5374.165305

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

外泌体:为神经保护和修复带来了新希望?

  

  • 收稿日期:2015-08-17 出版日期:2015-10-28 发布日期:2015-10-28

Exosomes in neurological disease, neuroprotection, repair and therapeutics: problems and perspectives

Anuradha Kalani*, Neetu Tyagi   

  1. Department of Physiology and Biophysics, School of Medicine,University of Louisville, Louisville, KY, USA
  • Received:2015-08-17 Online:2015-10-28 Published:2015-10-28
  • Contact: Anuradha Kalani, Ph.D.,anukalani@gmail.com, a0kala02@louisville.edu.

摘要:

微小囊泡中含有保护性物质,在神经元传送中起着非常重要的作用。细胞生物学家发现,神经细胞会寻求邻近的神经胶质细胞小囊泡的援助用来抵御压力和其他潜在的有害因素。这些囊泡称为外泌体,它们似乎在不同水平上刺激神经元,影响电刺激传导,生化信号传递和基因调控。外泌体因此是一种多功能信号发射器,它在大脑中有着至关重要的作用。
美国路易斯维尔大学Anuradha Kalani博士最新研究发现,外泌体包含独特的分子保存能力,它们可以反映出其来源细胞的病理生理学状态。此外,具有纳米尺寸和非复杂结构的外泌体可以有效地跨血脑屏障,因此外泌体的研究或许可为不同脑疾病的治疗提供了新的策略。

Abstract:

Exosomes have special cellular functions and neovascularization properties, angiogenetic potential and rejuvenating powers as stem cells do. Hence, devastating cerebral diseases can be challenged with exosomes in an individual-specific manner. Considering the enormous intriguing paracrine properties of exosomes, there is future probability of constructing an individual specific nano-vesicle banks that could help as therapy in lifetime of humans.