中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (12): 1945-1946.doi: 10.4103/1673-5374.172309

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

牙髓干细胞来源雪旺细胞可促进损伤周围神经再生

  

  • 收稿日期:2015-11-21 出版日期:2015-12-30 发布日期:2015-12-30

Dental pulp stem cells-derived schwann cells for peripheral nerve injury regeneration

Heba Al-Zer*, Heba Kalbouneh   

  1. Department of Conservative Dentistry, Faculty of Dentistry, University of Jordan, Amman, Jordan (Al-Zer H)
    Department of Anatomy and Histology, Faculty of Medicine, University of Jordan, Amman, Jordan (Kalbouneh H)
  • Received:2015-11-21 Online:2015-12-30 Published:2015-12-30
  • Contact: Heba Al-Zer, Ph.D., alzer_heba@yahoo.com.
  • Supported by:

    We thank Mrs Hala Shahrori for the graphics and artwork.

摘要:

牙髓位于牙齿内部的牙髓腔内,主要包含神经、血管等组织。约旦大学解剖学及组织学系Heba Al-Zer博士进行了一系列促牙髓干细胞向雪旺细胞分化的研究,作者建立了无血清培养方法,该方法提供了促进了牙髓干细胞的存活和增殖,同时消除了血清和酶消化引起的牙髓干细胞自发分化或死亡的影响。作者研究证实,从人牙髓干细胞分化而来的雪旺细胞能够促进受损周围神经再生。

Abstract:

The dental pulp of adult humans contains different stem cells populations, which show broad diversity and potentials. Here, the NC-derived DPSC population is discussed in term of their culturing method and induction of differentiation into SCs. The NC-derived DPSC population is to be recruited in the future for peripheral nerve injury regeneration after their induction into SCs in vitro. We recommend that these DPSC- derived SCs be considered as a superior alternative source of SCs compared with a nerve donor source. DPSCs are feasible, are cost and time efficient and do not require complicated surgical procedures.