中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (4): 636-640.doi: 10.4103/1673-5374.180750

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

脂氧素A4抗炎特性可改善糖尿病合并局灶性脑缺血的再灌注损伤

  

  • 收稿日期:2016-02-26 出版日期:2016-04-30 发布日期:2016-04-30
  • 基金资助:

    珠海市重点医学专科项目(200880)

Anti-inflammatory properties of lipoxin A4 protect against diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury

Jiang-quan Han*, Cheng-ling Liu, Zheng-yuan Wang, Ling Liu, Ling Cheng, Ya-dan Fan   

  1. Department of Neurology, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai, Guangdong Province, China
  • Received:2016-02-26 Online:2016-04-30 Published:2016-04-30
  • Contact: Jiang-quan Han, gdshanjq@163.com.
  • Supported by:

    This study was supported by a grant from the Zhuhai Key Discipline Project of China, No. 200880.

摘要:

脂氧素A4可通过降低炎症反应减轻脑缺血再灌注损伤,但其是否也对糖尿病合并的缺血再灌注损伤存在保护作用目前尚不清楚。为此,实验利用链脲佐菌素腹腔注射建立糖尿病模型大鼠,然后于大鼠大脑中动脉闭塞2h后再灌注24h,侧脑室立即注射脂氧素A4,观察发现脂氧素A4干预的大鼠大脑梗死体积减少,大脑皮质中促炎性细胞因子肿瘤坏死因子α和核因子κB表达下降,且神经功能明显改善。表明脂氧素A4能对糖尿病合并的脑缺血再灌注损伤有较强的保护作用,产生这一作用的机制与其抗炎特性有关。

orcid: 0000-0003-1532-1926 (Jiang-quan Han)

关键词: 神经再生, 脂氧素A4, 糖尿病, 脑缺血再灌注, 炎症反应, 肿瘤坏死因子α, 核因子κB

Abstract:

Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction, but it is currently unclear whether
it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury. In this study, we established rat
models of diabetes mellitus using an intraperitoneal injection of streptozotocin. We then induced focal cerebral ischemia/reperfusion
injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 hours. After administration of lipoxin A4 via the lateral
ventricle, infarction volume was reduced, the expression levels of pro-inflammatory factors tumor necrosis factor alpha and nuclear factor-
kappa B in the cerebral cortex were decreased, and neurological functioning was improved. These findings suggest that lipoxin A4 has
strong neuroprotective effects in diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury and that the underlying mechanism
is related to the anti-inflammatory action of lipoxin A4.

Key words: nerve regeneration, inflammatory response, tumor necrosis factor alpha, nuclear factor-kappa B, neural regeneration