中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (24): 1906-1913.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

急性脑梗死患者脑磁图听觉诱发磁场的变化

  

  • 收稿日期:2012-05-11 修回日期:2012-07-16 出版日期:2012-08-25 发布日期:2012-08-25

Changes of auditory evoked magnetic fields in patients after acute cerebral infarction using magnetoencephalography

Zhanyong Sun1, Chunfeng Song2, Jilin Sun3, Ling Li4, Yanhong Dong4, Jianhua Wang4, Jie Wu3, Wenzhu Cui4, Yujin Wu3, Peiyuan Lv1, 4   

  1. 1 Department of Neurology, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
    2 Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
    3 Department of Magnetoencephalography, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
    4 Department of Neurology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
  • Received:2012-05-11 Revised:2012-07-16 Online:2012-08-25 Published:2012-08-25
  • Contact: Peiyuan Lv, M.D., Professor, Chief physician, Doctoral supervisor, Department of Neurology, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China; Department of Neurology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China peiyuanlu@163.com
  • About author:Zhanyong Sun☆, M.D., Associate professor, Asso-ciate chief physician, Department of Neurology, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China

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Abstract:

Auditory evoked magnetic fields were recorded from 15 patients with acute cerebral infarction and 11 healthy volunteers using magnetoencephalography. The auditory stimuli of 2 kHz pure tone were binaurally presented with an interstimulus interval of 1 second. The intensity of stimuli was 90 dB and the stimulus duration was 8 ms. The results showed that the M100 was the prominent response, peaking approximately 100 ms after stimulus onset in all subjects. It originated from the area close to Heschl’s gyrus. In the patient group, the peak latency of M100 responses was significantly prolonged, and the mean strength of equivalent current dipole was significantly smaller in the affected hemisphere. The three-dimensional inter-hemispheric difference of the M100 positions was increased in the patient group. Our experimental findings suggested that impairment of cerebral function in patients with acute ischemic stroke can be detected using magnetoencephalography with the higher spatial resolution and temporal resolution. Magnetoencephalography could provide objective and sensitive indices to estimate auditory cortex function in patients with acute cerebral infarction.

Key words: acute cerebral infarction, cerebral ischemia, magnetoencephalography, auditory evoked magnetic fields, equivalent current dipole, Heschl’s gyrus, brain functional impairment, nerve injury, regeneration, neural regeneration