中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (6): 938-944.doi: 10.4103/1673-5374.208576

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

高频短脉冲刺激更能有效抑制皮质电刺激引起的后放电

  

  • 收稿日期:2017-05-11 出版日期:2017-06-15 发布日期:2017-06-15
  • 基金资助:

     

    首都卫生发展科研专项项目(2016-1-2011

High-frequency and brief-pulse stimulation pulses terminate cortical electrical stimulation-induced afterdischarges

Zhi-wei Ren, Yong-jie Li, Tao Yu, Duan-yu Ni, Guo-jun Zhang, Wei Du, Yuan-yuan Piao, Xiao-xia Zhou   

  1. Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China
  • Received:2017-05-11 Online:2017-06-15 Published:2017-06-15
  • Contact: Yong-jie Li, geekai@163.com.
  • Supported by:

    This work was supported by the Capital Health Research and Development Special Funds of China, No. 2016-1-2011.

摘要:

既往研究中多采用50Hz的短脉冲刺激终止癫痫患者的后放电,但这是否为抑制皮质电刺激引起后放电的最佳刺激参数,目前尚无结论。试验为观察不同频率刺激对人大脑皮质电刺激引起后放电的影响,通过5,50,100 Hz短脉冲刺激对10例难治性癫痫患者后放电进行干预。结果发现短脉冲电刺激可以抑制皮质电刺激过程中诱发的后放电,其中100 Hz短脉冲电刺激比5和50 Hz短脉冲电刺激更能有效抑制皮质电刺激引起的后放电,显示其可能对早期癫痫有更好的治疗效果。

ORCID:0000-0001-8889-3568(Yong-jie Li)

关键词: 神经再生, 皮质电刺激, 后放电, 顽固性癫痫, 脑功能成像, 高频刺激, 低频刺激, 神经调节

Abstract:

Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies (5, 50 and 100 Hz) on cortical electrical stimulation-induced afterdischarges in 10 patients with refractory epilepsy. Results demonstrated that brief-pulse stimulation could terminate cortical electrical stimulation-induced afterdischarges in refractory epilepsy patients. In conclusion, (1) a brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area. (2) A higher brief-pulse stimulation frequency (especially 100 Hz) was more likely to terminate an afterdischarge. (3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge.

Key words: nerve regeneration, cortical electrical stimulation, afterdischarges, intractable epilepsy, functional brain mapping, high frequency stimulation, low frequency stimulation, neuromodulation, neural regeneration