中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (7): 1097-1102.doi: 10.4103/1673-5374.211188

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

血清前白蛋白: 有效评估出血性脑卒中患者的病情与临床预后

  

  • 收稿日期:2017-05-27 出版日期:2017-07-15 发布日期:2017-07-15
  • 基金资助:

    中国国家自然科学基金项目（81571147），美国心脏协会基金项目（14FTF19970029）

Serum prealbumin as an effective prognostic indicator for determining clinical status and prognosis in patients with hemorrhagic stroke

Shen-qi Zhang1, Bin Peng2, Creed M. Stary3, Zhi-hong Jian1, Xiao-xing Xiong1, Qian-xue Chen1   

  1. 1 Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; 2 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; 3 Department of Anesthesiology, Stanford University School of Medicine, Palo Alto, CA, USA
  • Received:2017-05-27 Online:2017-07-15 Published:2017-07-15
  • Contact: Xiao-xing Xiong, Ph.D., M.D., xiaoxingxiong@whu.edu.cn.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 81571147; an American Heart Association Award, No. 14FTF19970029.

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摘要：

血清前白蛋白是营养不良的指标之一，在损伤急性期反应期水平下降，但其对于出血性脑卒中预后效果的评价价值尚不确定。因此我们回顾性分析了武汉大学人民医院2015年1至12月收治的105例出血性脑卒中患者的临床资料，记录入院第1，3，6，9，14-21天时的血清前白蛋白水平，同时记录患者出现感染、消化道出血等并发症及出院情况。发现住院期间感染患者血清前白蛋白水平低于未感染患者，伴有消化道出血患者血清前白蛋白水平低于无消化道出血患者，出院时恢复良好患者血清前白蛋白水平高于欠佳的患者。说明动态检测血清前白蛋白水平，可以有效评估出血性脑卒中患者的病情程度和临床预后。

ORCID:0000-0001-6983-8547(Xiao-xing Xiong)

关键词: 神经再生, 前白蛋白, 出血性脑卒中, 感染, 消化道出血, 预后标志物, 预后

Abstract:

Serum prealbumin is a recognized marker of malnutrition, but its prognostic role in patients with hemorrhagic stroke remains unclear. In this study, we retrospectively reviewed the records of 105 patients with hemorrhagic stroke admitted to Renmin Hospital of Wuhan University, China, from January to December 2015. We collected demographic and radiological data, and recorded serum prealbumin levels at admission and on days 1, 3, 6, 9, and 14–21. The existence of infections and gastrointestinal hemorrhage, and clinical condition at discharge were also recorded. Serum prealbumin levels during hospitalization were significantly lower in patients with infections compared with those without infections, and also significantly lower in patients with gastrointestinal hemorrhage compared with those without. Serum prealbumin levels at discharge were significantly higher in patients with good recovery than in those with poor recovery. We conclude that regular serum prealbumin measurements in patients with hemorrhagic stroke may be a useful indicator for determining clinical status and prognosis, which may therefore help to guide clinical decision-making.

Key words: nerve regeneration, prealbumin, hemorrhagic stroke, infection, gastrointestinal hemorrhage, prognostic indicator, prognosis, neural regeneration