中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (on line): 1-6.

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The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study

  

  • 出版日期:2023-01-01 发布日期:2022-09-16

Zhen-Chao Tang1, 2, 3, #, Jiao-Jiao Liu4, #, Xue-Tong Ding1, 2, 3, #, Dan Liu5 , Hong-Wei Qiao6 , Xiao-Jie Huang4 , Hui Zhang1, 2, 3, *, Jie Tian1, 2, 3, *, Hong-Jun Li4, *   

  1. 1 Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China; 2 Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China, Beijing, China; 3 Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; 4 Beijing YouAn Hospital, Capital Medical University, Beijing, China5Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 6 Institute of Laboratory Animal Sciences, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Beijing, China
  • Online:2023-01-01 Published:2022-09-16
  • Contact: Hong-Jun Li, MD, lihongjun00113@ccmu.edu.cn; Jie Tian, PhD, tianj@buaa.ed.cn; Hui Zhang, PhD, hui.zhang@buaa.edu.cn.
  • Supported by:
    This study was supported by the National Natural Science Foundation of China, Nos. 81771806 (to HJL), 61936013 (to HJL), 82001914 (to ZCT), 81871511 (to HZ); and the Beijing Natural Science Foundation.

Abstract:

Acquired immune deficiency syndrome (AIDS) infection can lead to cognitive dysfunction represented by changes in the default mode network (DMN). Most recent studies have been cross-sectional and thus have not revealed dynamic changes in the DMN following AIDS infection and antiretroviral therapy (ART). Specifically, when brain imaging data at only one time point are analyzed, determining the duration at which the DMN is the most effective following ART after the occurrence of AIDS. However, because infection times and other factors are often uncertain, longitudinal studies cannot be conducted directly in the clinic. Therefore, in this study, we performed a longitudinal study on the dynamic changes in the DMN over time in a rhesus monkey model of simian immunodeficiency virus (SIV) infection. We found marked changes in DMN connectivity in 11 pairs of regions of interest (ROIs) at baseline and 10 days and 4 weeks after virus inoculation. Significant interactions between treatment and time were observed in the DMN connectivity of ROI pairs area 31/V6.R and area 8/ Frontal eye field (FEF).L, area 8/FEF.L and caudal temporal parietal occipital area (TPOC).R, and area 31/V6.R and TPOC.L. ART administered 4 weeks after infection not only interrupted the progress of SIV infection but also preserved brain function to a large extent. These findings suggest that the DMN is affected in the early stage of SIV infection and that it may serve as a potential biomarker for early changes in brain function and an objective indicator for making early clinical intervention decisions.

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