中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1666-1671.doi: 10.4103/1673-5374.363825

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

单核细胞在视神经损伤中的作用

  

  • 出版日期:2023-08-15 发布日期:2023-02-16

The role of monocytes in optic nerve injury

Xiangxiang Liu1, 2, Yuan Liu2, Mohamed M. Khodeiry2, Richard K. Lee2, *   

  1. 1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China; 2Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA
  • Online:2023-08-15 Published:2023-02-16
  • Contact: Richard K. Lee, MD, PhD, rlee@med.miami.edu.
  • Supported by:
    The Bascom Palmer Eye Institute was supported by NIH Center Core Grant P30EY014801 and a Research to Prevent Blindness Unrestricted Grant. RKL is partially supported by the Walter G. Ross Foundation. This work was partly supported by the Gutierrez Family Research Fund, the Camiener Family Glaucoma Research Fund, and the National Natural Science Foundation of China (No. 82201170 to XL).

摘要: https://orcid.org/0000-0002-9813-7536 (Richard K. Lee) 

Abstract: Monocytes, including monocyte-derived macrophages and resident microglia, mediate many phases of optic nerve injury pathogenesis. Resident microglia respond first, followed by infiltrating macrophages which regulate neuronal inflammation, cell proliferation and differentiation, scar formation and tissue remodeling following optic nerve injury. However, microglia and macrophages have distinct functions which can be either beneficial or detrimental to the optic nerve depending on the spatial context and temporal sequence of their activity. These divergent effects are attributed to pro- and anti-inflammatory cytokines expressed by monocytes, crosstalk between monocyte and glial cells and even microglia-macrophage communication. In this review, we describe the dynamics and functions of microglia and macrophages in neuronal inflammation and regeneration following optic nerve injury, and their possible role as therapeutic targets for axonal regeneration.

Key words: fibrotic scar, glial scar, inflammation, macrophage, microglia, optic nerve injury, regeneration