中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (6): 1277-1283.doi: 10.4103/1673-5374.382987

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

纹状体中间神经元的双重作用:基底节的回路调节和营养支持 

  

  • 出版日期:2024-06-15 发布日期:2023-11-17

The dual role of striatal interneurons: circuit modulation and trophic support for the basal ganglia

Elliot Wegman1, Marlena Wosiski-Kuhn2, Yu Luo1, 3, *   

  1. 1Department of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH, USA; 2Department of Emergency Medicine at the School of Medicine, University of Cincinnati, Cincinnati, OH, USA; 3Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH, USA
  • Online:2024-06-15 Published:2023-11-17
  • Contact: Yu Luo, PhD, LUOY2@ucmail.uc.edu.

摘要: https://orcid.org/0000-0002-7939-5505 (Yu Luo)

Abstract: Striatal interneurons play a key role in modulating striatal-dependent behaviors, including motor activity and reward and emotional processing. Interneurons not only provide modulation to the basal ganglia circuitry under homeostasis but are also involved in changes to plasticity and adaptation during disease conditions such as Parkinson’s or Huntington’s disease. This review aims to summarize recent findings regarding the role of striatal cholinergic and GABAergic interneurons in providing circuit modulation to the basal ganglia in both homeostatic and disease conditions. In addition to direct circuit modulation, striatal interneurons have also been shown to provide trophic support to maintain neuron populations in adulthood. We discuss this interesting and novel role of striatal interneurons, with a focus on the maintenance of adult dopaminergic neurons from interneuron-derived sonic-hedgehog.   

Key words: cholinergic, dopamine, GABAergic, interneuron, levodopa-induced dyskinesia, parvalbumin, sonic hedgehog, striatum, trophic factor