中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (21): 1630-1636.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis

  

  • 收稿日期:2012-02-15 修回日期:2012-05-13 出版日期:2012-07-25 发布日期:2012-07-25

Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis

Yunying Qiao1, Fudong Wu2, Jian Wang2, Xiaolu Cui2, Congcong Liu2, Xinlong Zhu2   

  1. 1  Department of Acupuncture and Moxibustion, Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China
    2  Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
  • Received:2012-02-15 Revised:2012-05-13 Online:2012-07-25 Published:2012-07-25
  • Contact: Yunying Qiao, Department of Acupuncture and Moxibustion, Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China qiaoyunying@sohu.com
  • About author:Yunying Qiao☆, M.D., Lecturer, Department of Acupuncture and Moxibustion, Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China

PDF

725

Abstract:

Rat models of adjuvant arthritis were established, and anti-corticotropin release hormone serum injection in the lateral ventricles and electroacupuncture at right Jiaji (EX-B2) were performed. The pain threshold was decreased at 45 and 60 minutes after injection of the anti-corticotropin release hormone serum. Electroacupuncture at Jiaji can resist this effect. Immunohistochemical staining results showed that the expression of corticotropin release hormone in the hypothalamic paraventricular nucleus was greater in the electroacupuncture + anti-corticotropin release hormone serum group compared with the anti-corticotropin release hormone serum group. The expression of corticotropin release hormone was correlated with the pain threshold. The effect of endogenous corticotropin release hormone in pain modulation can be obstructed by anti-corticotropin release hormone serum. The analgesia of electroacupuncture can partially resist the depressed pain threshold caused by injection of anti-corticotropin release hormone serum. The analgesic effect of electroacupuncture is associated with the corticotropin release hormone content in the hypothalamus.

Key words: endogenous corticotropin release hormone, electroacupuncture, adjuvant arthritis, analgesia, hypothalamus, neuron, neural regeneration