中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1643-1644.doi: 10.4103/1673-5374.389640

• 观点:退行性病与再生 • 上一篇    下一篇

单体C反应蛋白:慢性炎症和神经退行性变之间的联系?

  

  • 出版日期:2024-08-15 发布日期:2024-01-03

Monomeric C-reactive protein: a link between chronic inflammation and neurodegeneration?

Nicoleta Arnaut, Ylenia Pastorello, Mark Slevin*   

  1. George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu Mures, Romania (Arnaut N) 
    Department of Anatomy and Embryology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu Mures, Romania (Pastorello Y) 
    Center for Advanced Medical and Pharmaceutical Research (CCAMF), George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu Mures, Romania (Slevin M)
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Mark Slevin, PhD, mark.slevin@umfst.ro.

摘要: https://orcid.org/0000-0003-3767-4861 (Mark Slevin)

Abstract: Pre-diabetic insulin resistance is associated with sub-clinical inflammation and concomitant increase in systemic C-reactive protein (CRP) levels. Type 2 diabetes mellitus (T2DM) patients register even higher chronic levels of inflammation, with excess circulating CRP originating from both typical hepatic synthesis, and also visceral white adipose tissue. In addition, infiltration of pro-inflammatory macrophages into the expanding fat, as obesity becomes morbid, contributes further to dysregulation and symptomatic disease (Stanimirovic et al., 2022). Most importantly, in diabetic individuals, a sustained and chronic inflammation is perpetuated in the presence of non-healing wounds and ulcers, with associated further increase in CRP (Dangwal et al., 2015).