中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1734-1740.doi: 10.4103/1673-5374.389625

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

调节神经免疫血栓形成的中性粒细胞外诱捕网

  

  • 出版日期:2024-08-15 发布日期:2024-01-03
  • 基金资助:
    国家自然科学基金项目;天津市应用基础与支撑研究项目;天津市教育委员会科学研究计划(自然科学)项目;天津市科技计划项目(自然科学) ;中国天津市教育委员会科学研究计划(自然科学);天津市创新人才培养科技计划(自然科学);天津市创新人才培养科技计划项目;天津医科大学 "临床人才培养 123 攀登计划";天津市医疗卫生精英杰出青年医生发展计划;中青年骨干创新人才计划

Neutrophil extracellular traps mediate neuro-immunothrombosis

Jianbo Lou1, Jianning Zhang1, 2, Quanjun Deng1, *, Xin Chen1, 2, *   

  1. 1Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China; 2Tianjin Neurological Institute, Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, China
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Quanjun Deng, MD, dqj2177@163.com; Xin Chen, MD, PhD, xinchentianjin@163.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 82271399 (to XC), the Project of Tianjin Applied Basic and Multiple Support Research, No. 21JCZDJC00910 (to XC), the Scientific Research Program of Tianjin Education Commission (Natural Science) of China, No.  2019ZD034 (to QD), the Science & Technology Program of Tianjin for Cultivation of Innovative Talents, No. 22JRRCRC00020 (to QD), the Tianjin Medical University “Clinical Talent Training 123 Climbing Plan” (to XC), the Tianjin Health Care Elite Prominent Young Doctor Development Program (to XC), and the Young and Middle-aged Backbone Innovative Talent Program  (to XC).

摘要:

中性粒细胞外诱捕网是由中性粒细胞产生的以脱氧核糖核酸和组蛋白为主要成分的网状物质,与机体炎症反应及血栓形成密切相关。在中性粒细胞外诱捕网发挥炎症或血栓形成作用的过程中,与血小板、血管性血小板因子、纤维蛋白等物质协同,共同调节炎症反应和免疫血栓形成。在目前针对脑出血、脑血管疾病等已有的相关研究中,中性粒细胞外诱捕网在中枢神经系统免疫血栓形成中发挥作用。并且血脑屏障的破坏使得中性粒细胞外诱捕网的活动受限减少,使中性粒细胞外诱捕网得以更广泛地产生作用。创伤性脑损伤后患者的脑血管、血脑屏障受到损害,同时创伤性脑损伤后的血循环障碍通常使得患者预后不良。创伤性脑损伤后免疫血栓的形成,是导致创伤性脑损伤不良预后的一个重要病理生理机制,然而中性粒细胞外诱捕网与创伤性脑损伤后免疫血栓形成间的相互作用机制研究并不十分明确。文章首先总结了中性粒细胞外诱捕网的生成机制,中性粒细胞外诱捕网的生成异常与机体内的炎症反应及血栓形成密切相关。其次,聚焦于中性粒细胞外诱捕网在神经系统疾病,尤其是脑血管相关疾病中的作用。探索中性粒细胞外诱捕网在创伤性脑损伤中的作用机制将有助于深入了解创伤性脑损伤后机体的病理生理变化规律,改善创伤性脑损伤的不良预后。

https://orcid.org/0000-0002-8718-1857 (Quanjun Deng); https://orcid.org/0000-0002-1720-1226 (Xin Chen)

Abstract: Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions. Neutrophil extracellular trap formation occurs through lytic and non-lytic pathways that can be further classified by formation mechanisms. Histones, von Willebrand factor, fibrin, and many other factors participate in the interplay between inflammation and thrombosis. Neuro-immunothrombosis summarizes the intricate interplay between inflammation and thrombosis during neural development and the pathogenesis of neurological diseases, providing cutting-edge insights into post-neurotrauma thrombotic events. The blood-brain barrier defends the brain and spinal cord against external assaults, and neutrophil extracellular trap involvement in blood-brain barrier disruption and immunothrombosis contributes substantially to secondary injuries in neurological diseases. Further research is needed to understand how neutrophil extracellular traps promote blood-brain barrier disruption and immunothrombosis, but recent studies have demonstrated that neutrophil extracellular traps play a crucial role in immunothrombosis, and identified modulators of neuro-immunothrombosis. However, these neurological diseases occur in blood vessels, and the mechanisms are unclear by which neutrophil extracellular traps penetrate the blood-brain barrier to participate in immunothrombosis in traumatic brain injury. This review discusses the role of neutrophil extracellular traps in neuro-immunothrombosis and explores potential therapeutic interventions to modulate neutrophil extracellular traps that may reduce immunothrombosis and improve traumatic brain injury outcomes.

Key words: inflammation, neuro-immunothrombosis, neurologic diseases, neurotrauma, neutrophil extracellular traps, platelet, thrombosis, traumatic brain injury