中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (3): 725-739.doi: 10.4103/NRR.NRR-D-23-02068

• 综述:退行性病与再生 • 上一篇    下一篇

Spastin和alsin蛋白相互作用组分析开始揭示关键的经典途径，并提出新的药物靶点

  

  • 出版日期:2025-03-15 发布日期:2024-06-25

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

Benjamin R. Helmold1 , Angela Ahrens1 , Zachary Fitzgerald1 , P. Hande Ozdinler1, 2, 3, 4, *   

  1. 1 Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 2 Center for Molecular Innovation and Drug Discovery, Center for Developmental Therapeutics, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA; 3 Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 4 Feinberg School of Medicine, Les Turner ALS Center at Northwestern University, Chicago, IL, USA
  • Online:2025-03-15 Published:2024-06-25
  • Contact: P. Hande Ozdinler, PhD, ozdinler@northwestern.edu.
  • Supported by:
    This work was funded by NIH-NIA R01AG061708 (to PHO), Patrick Grange Memorial Foundation (to PHO), A Long Swim (to PHO), and CureSPG4 Foundation (to PHO).

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摘要： https://orcid.org/0000-0003-4125-6013 (P. Hande Ozdinler)

Abstract: Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying diseasecausing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein– protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration– approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

Key words: ALS2, alsin,  amyotrophic lateral sclerosis,  hereditary spastic paraplegia,  neurodegenerative diseases,  personalized medicine,  precision medicine,  protein interactome,  protein-protein interactions,  SPAST,  spastin