中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (6): 1699-1700.doi: 10.4103/NRR.NRR-D-24-00378

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

硫酸软骨素蛋白聚糖信号传导在脊髓损伤神经干细胞介导修复中的作用及其机制的新见解

  

  • 出版日期:2025-06-15 发布日期:2024-11-12

New insights on the role of chondroitin sulfate proteoglycans in neural stem cell–mediated repair in spinal cord injury

Seyed Mojtaba Hosseini, Soheila Karimi-Abdolrezaee*   

  1. Department of Physiology and Pathophysiology, Spinal Cord Research Centre, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada (Hosseini SM, Karimi-Abdolrezaee S) Manitoba Multiple Sclerosis Research Center, Winnipeg, MB, Canada (Hosseini SM, Karimi-Abdolrezaee S) Children Hospital Research Institute of Manitoba, Winnipeg, MB, Canada (Karimi-Abdolrezaee S)
  • Online:2025-06-15 Published:2024-11-12
  • Contact: Soheila Karimi-Abdolrezaee, PhD, Soheila.Karimi@umanitoba.ca.
  • Supported by:
    SKA acknowledges funding support from the Canadian Institutes of Health Research. SMH was supported by a Doctoral Studentship from the Wings for Life Foundation.

摘要: https://orcid.org/0000-0002-0683-2663 (Soheila Karimi-Abdolrezaee)

Abstract: Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al., 2019). Following the primary impact, the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood–spinal cord barrier, vascular injury, glial reactivity, neuroinflammation, oxidative stress, lipid peroxidation, and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death, demyelination, and axonal damage (Alizadeh et al., 2019). To achieve a meaningful functional recovery after SCI, regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al., 2020).