中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (6): 1701-1702.doi: 10.4103/NRR.NRR-D-24-00373

• 观点:退行性病与再生 • 上一篇    下一篇

磷酸二酯酶9在细胞质和细胞核中的定位:神经保护中选择性靶向的途径?

  

  • 出版日期:2025-06-15 发布日期:2024-11-12

Phosphodiesterase 9 localization in cytoplasm and nucleus: the gateway to selective targeting in neuroprotection?

Giovanni Ribaudo* , Matteo Giannangeli, Margrate Anyanwu, Alessandra Gianoncelli   

  1. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
  • Online:2025-06-15 Published:2024-11-12
  • Contact: Giovanni Ribaudo, PhD, giovanni.ribaudo@unibs.it.

摘要: https://orcid.org/0000-0003-3679-5530 (Giovanni Ribaudo)

Abstract: T h e u m b re l l a t e r m “ n e u ro d e g e n e ra t i v e disorders” (NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system. Such diseases affect more than 50 million people worldwide. Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that are challenging to be fully profiled. Many of these rely on cell signaling pathways to preserve homeostasis, involving second messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine 3′,5′-monophosphate (cGMP). Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors. Protein kinases A and G (PKA and PKG), phosphodiesterases (PDEs), and scaffold proteins are among them.