中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (6): 1709-1710.doi: 10.4103/NRR.NRR-D-24-00436

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

小脑突触中超长链脂肪酸功能的新见解

  

  • 出版日期:2025-06-15 发布日期:2024-11-12

Emerging insights into the function of very long chain fatty acids at cerebellar synapses

Martin-Paul Agbaga* , Mohiuddin Ahmad*   

  1. Department of Cell Biology and Ophthalmology, University of Oklahoma Health Sciences Center, and Dean McGee Eye Institute, Oklahoma City, OK, USA
  • Online:2025-06-15 Published:2024-11-12
  • Contact: Martin-Paul Agbaga, PhD, martin-paul-agbaga@ouhsc.edu; Mohiuddin Ahmad, PhD, mohiuddin-ahmad@ouhsc.edu.
  • Supported by:
    This work was supported by NEI/NIH R01 EY030513; NIAMS/NIH R21-AR076035; MultiPI Team Science grant from Presbyterian Health Foundation.

摘要: https://orcid.org/0000-0002-1920-915X (Martin-Paul Agbaga) https://orcid.org/0000-0002-0976-9620 (Mohiuddin Ahmad)

Abstract: Very long chain-saturated and -polyunsaturated fatty acids (VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4 (ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found (Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility (Yeboah et al., 2021).