中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (6): 1707-1708.doi: 10.4103/NRR.NRR-D-24-00217

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

解锁低血糖相关的脑微血管功能障碍:蛋白质组学分析的关键见解

  

  • 出版日期:2025-06-15 发布日期:2024-11-12

Unlocking hypoglycemia–associated brain microvascular dysfunction: critical insights from proteomic analysis

Siva S.V.P. Sakamuri* , Anil Sakamuri   

  1. Department of Chemistry, Auburn University at Montgomery, Montgomery, AL, USA (Sakamuri SSVP) Vascular Biology Center and Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA (Sakamuri A)
  • Online:2025-06-15 Published:2024-11-12
  • Contact: Siva S.V.P. Sakamuri, PhD, ssakamur@aum.edu.
  • Supported by:
    This work was generously supported by the faculty startup funds from Auburn University at Montgomery (to SSVPS).

摘要: https://orcid.org/0000-0003-3569-9985 (Siva S.V.P. Sakamuri)

Abstract: Hypoglycemia – a critical complication linked to worsened brain function in diabetic subjects: Hypoglycemia is characterized by a decline in circulatory glucose levels below standard physiological thresholds. Mild hypoglycemia, classified as level 1 hypoglycemia, is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate intake. Severe hypoglycemia, denoted by blood glucose levels less than 54 mg/dL, poses a life-threatening risk if left untreated. Individuals with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms. According to International Hypoglycemia Study Group, nearly 40% of type 1 diabetic individuals and 20% of type 2 diabetic individuals with a history of insulin treatment exceeding five years may develop severe hypoglycemia as a complication. Notably, recurrent occurrences of mild hypoglycemia are more prevalent in diabetic subjects compared to instances of severe hypoglycemia (Brazeau et al., 2022).