中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (7): 2108-2115.doi: 10.4103/NRR.NRR-D-22-00867

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

FK506抑制神经炎症反应促进神经元存活和周围神经再生

  

  • 出版日期:2025-07-15 发布日期:2024-11-27

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

Yuhui Kou1, 2, 3, #, Zongxue Jin2, 4, #, Yusong Yuan5, #, Bo Ma1, 3, Wenyong Xie1 , Na Han2, 3, *   

  1. 1 Department of Trauma and Orthopedics, Peking University People’s Hospital, Beijing, China;  2 National Center for Trauma Medicine, Peking University People’s Hospital, Beijing, China;  3 Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of Education, Beijing, China;  4 Trauma Medicine Center, Peking University People’s Hospital, Beijing, China;  5 Department of Orthopedics, China-Japan Friendship Hospital, Beijing, China
  • Online:2025-07-15 Published:2024-11-27
  • Contact: Na Han, PhD, hannaqa@hotmail.com.
  • Supported by:
    This study was continuously supported by the National Natural Science Foundation of China, No. 81971177 (to YK); the Natural Science Foundation of Beijing, No. 7222198 (to NH); and the Peking University People’s Hospital Research and Development Fund, No. RDX2021-01 (to YK).

摘要:

FK506(他克莫司)是一种经美国食药监局批准的系统性免疫抑制剂,既往有研究发现FK506能促进周围神经再生,但其具体的作用机制和途径尚不清楚。此次实验以坐骨神经损伤大鼠为模型,结果显示,FK506治疗改善了损伤坐骨神经的形态,增加运动神经元和感觉神经元数量,减轻炎症反应,明显改善损伤神经传导功能,并促进运动功能的恢复。由此提示,FK506是通过抑制神经元损伤后的炎症强度,增加存活神经元的数量,达到促进周围神经结构和功能再生的作用。

https://orcid.org/0000-0003-4590-3361 (Na Han)

关键词: 周围神经损伤,  FK506,  神经元,  炎症,  神经再生,  运动神经元,  感觉神经元

Abstract: FK506 (Tacrolimus) is a systemic immunosuppressant approved by the U.S. Food and Drug Administration. FK506 has been shown to promote peripheral nerve regeneration, however, its precise mechanism of action and its pathways remain unclear. In this study, we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve, increased the numbers of motor and sensory neurons, reduced inflammatory responses, markedly improved the conduction function of the injured nerve, and promoted motor function recovery. These findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

Key words: FK506,  inflammation,  motor neurons,  nerve regeneration,  neuron,  peripheral nerve injury,  sensory neurons