中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (2): 687-688.doi: 10.4103/NRR.NRR-D-24-01240

• 观点:退行性病与再生 • 上一篇    下一篇

迈向基于机制的tau靶向治疗

  

  • 出版日期:2026-02-15 发布日期:2025-05-23

Towards mechanism-based tautargeted therapies

Lidia Bakota, Roland Brandt*   

  1. Department of Neurobiology, School of Biology/ Chemistry, Osnabrück University, Osnabrück, Germany (Bakota L, Brandt R) Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany (Brandt R) Institute of Cognitive Science, Osnabrück University, Osnabrück, Germany (Brandt R)
  • Online:2026-02-15 Published:2025-05-23
  • Contact: Roland Brandt, PhD, robrandt@uni-osnabrueck.de.

摘要: https://orcid.org/0000-0003-0101-1257 (Roland Brandt)

Abstract: T a u p l a y s a c r u c i a l r o l e i n s e v e r a l neurodegenerative diseases, collectively referred to as tauopathies. Therefore, targeting potential pathological changes in tau could enable useful therapeutic interventions. However, tau is not an easy target because it dynamically interacts with microtubules and other cellular components, which presents a challenge for tau-targeted drugs. New cellular models could aid the development of mechanism-based tau-targeted therapies.