中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (7): 2940-2941.doi: 10.4103/NRR.NRR-D-25-00651

• 观点:退行性病与再生 • 上一篇    下一篇

FKBP51:帕金森病的新靶点

  

  • 出版日期:2026-07-15 发布日期:2026-03-27

FKBP51: A new target for Parkinson’s disease

Marta Garcia-Gomara, Mar Cuadrado-Tejedor*, Ana Garcia-Osta*   

  1. Gene Therapy for CNS Disorders program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain
    IdiSNA (Navarra Institute for Health Research), Pamplona, Spain
    Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain
  • Online:2026-07-15 Published:2026-03-27
  • Contact: Ana Garcia-Osta, PhD,agosta@unav.es; Mar Cuadrado-Tejedor, PhD,mcuadrado@unav.es.
  • Supported by:
    This work was supported by PID2022-138285OB-I00, financiado por MCIN/AEI/10.13039/501100011033/FEDER, UE to AGO and MCT, and by Asociación de Amigos fellowship grant to MGG.

摘要: https://orcid.org/0000-0003-4387-646X (Marta Garcia-Gomara)
https://orcid.org/0000-0001-6326-9064 (Ana Garcia-Osta)
https://orcid.org/0000-0003-4260-9140 (Mar Cuadrado-Tejedor)
 

Abstract: Parkinson’s disease (PD) is a progressive age-related neurodegenerative disorder clinically defined by motor symptoms and pathologically by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta. These neurons are characterized by the presence of the cytoplasmic pigment neuromelanin (NM), and their degeneration is closely associated with the accumulation of α-synuclein (α-syn) into intraneuronal inclusions known as Lewy bodies (LBs), which represent a neuropathological hallmark of PD.