中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (12): 2077-2079.doi: 10.4103/1673-5374.241447

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

ATP是调节神经元支持轴突再生的关键因素吗?

  

  • 收稿日期:2018-08-16 出版日期:2018-12-15 发布日期:2018-12-15

Is ATP a key player in conditioning neurons to support axonal regeneration?

Xuenong Bo   

  1. Centre for Neuroscience and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Received:2018-08-16 Online:2018-12-15 Published:2018-12-15
  • Contact: Xuenong Bo, MB, MSc, PhD, x.bo@qmul.ac.uk

摘要:

orcid: 0000-0002-9202-3562 (Xuenong Bo)

Abstract:

Neurons in the central nervous system (CNS) of adult mammals have a weak intrinsic regenerative capacity, which is one contributing factor to the failure of axonal regeneration. Finding the means to elevate the regenerative capacity of axotomised neurons is one requirement for successful regeneration. Forty-five years ago, it was reported that crushing of the sciatic nerves of adult mice two weeks before cutting the nerves accelerated the regrowth of their axons (McQuarrie and . The nerve injury two weeks before triggered the regeneration machinery in the injured neurons, leading to faster axonal regrowth after a subsequent lesion. Later it was found that a lesion to a peripheral nerve also strongly enhanced the regeneration of the central branches of the appropriate primary sensory neurons . This phenomenon is termed preconditioning lesion (or conditioning lesion if the central branches of the sensory neurons are injured after a concomitant injury to their peripheral branches). Conditioning lesion of peripheral nerves has been used in combination with other strategies in promoting sensory axon regeneration in injured spinal cord in animal models. Although conditioning lesion cannot be translated into clinical practice as intentional injury to the peripheral nerves of the patients would be counterproductive, studying the underlying molecular events will reveal how neurons respond to axonal injuries, leading to the development of practical therapeutic strategies for axonal regeneration.