中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (12): 2080-2082.doi: 10.4103/1673-5374.241452

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

硫酸软骨素蛋白多糖信号在调节脊髓损伤后神经炎症中的作用

  

  • 收稿日期:2018-08-07 出版日期:2018-12-15 发布日期:2018-12-15

Role of chondroitin sulfate proteoglycan signaling in regulating neuroinflammation following spinal cord injury

Scott M. Dyck, Soheila Karimi-Abdolrezaee   

  1. Department of Physiology and Pathophysiology, the Regenerative Medicine Program, the Spinal Cord Research Center, University of Manitoba, Winnipeg, Manitoba, Canada
  • Received:2018-08-07 Online:2018-12-15 Published:2018-12-15
  • Contact: Soheila Karimi-Abdolrezaee, PhD, Soheila.Karimi@umanitoba.ca.
  • Supported by:

    This work was supported by the Craig H. Neilsen Foundation awarded to SKA. SMD was supported by a joint studentship from Will-to-Win/Manitoba Paraplegic Foundation and the Children’s Hospital Research Institute of Manitoba.

摘要:

orcid: 0000-0002-0683-2663 (Soheila Karimi-Abdolrezaee)

Abstract:

Spinal cord injury (SCI) elicits a robust inflammatory response that is a hallmark of the secondary injury mechanisms. Neuroinflammation is orchestrated initially by the response of resident astrocytes and microglia to injury, which subsequently facilitates the recruitment of peripheral immune cells into the SCI lesion . This inflammatory response contributes to cell death and tissue degeneration through the production of pro-inflammatory cytokines and chemokines, free radicals and proteolytic enzymes. However, neuroinflammatory cells also play beneficial regulatory role in repair mechanisms after SCI by adopting a reparative and wound healing phenotype. Hence, understanding the underlying mechanisms by which immune cells are regulated within the microenvironment of injury would aid in harnessing the reparative potential of inflammation following SCI.