中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (1): 82-84.doi: 10.4103/1673-5374.244788

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

通过支链氨基酸维持ATP作为视网膜神经退行性疾病的新型神经保护策略

  

  • 出版日期:2019-01-15 发布日期:2019-01-15

Adenosine triphosphate maintenance by branched chain amino acids as a novel neuroprotective strategy for retinal neurodegenerative diseases

Tomoko Hasegawa1, Hanako Ohashi Ikeda1, 2   

  1. 1 Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan;
    2 Department of Experimental Therapeutics, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Hanako Ohashi Ikeda, MD, PhD, hanakoi@kuhp.kyoto-u.ac.jp.
  • Supported by:

    This research was supported by the Japan Agency for Med-ical Research and Development (to HOI).

摘要:

orcid: 0000-0001-9572-8659 (Hanako Ohashi Ikeda)

Abstract:

Retinal neuronal cell death is caused in many incurable eye diseases such as retinitis pigmentosa (RP) and glau-coma, which are leading causes of adult blindness. In RP, progressive loss of photoreceptor cells leads to visual dis-turbance. No established treatments are available to date for this condition, although potential treatments, includ-ing regenerative medicine, gene therapy, and neurotropic factor therapy are being investigated. In glaucoma, retinal ganglion cell death leads to visual disturbance. Although intraocular pressure reduction is the only established treatment to slow the loss of visual function in glaucoma, there are a fair number of cases where visual impairment progresses despite intraocular pressure being maintained within the normal range. Therapeutic strategies to pre-vent neuronal cell death are being pursued.